Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. The most compelling evidence linking Ca defects with cell death in ALS is excitotoxicity caused by glial cells (). Huntington&aposs disease is a genetic disorder characterized by an increased number (over 40) of glutamine amino acids at the N-terminus of the huntingtin protein (Htt), which affect the medium spiny neurons. Expanded Htt binds to IP3R, which increases its sensitivity to IP3, thereby stimulating Ca effl
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In this Review, we discuss the current evidence that implicates defective Ca homeostasis in the pathogenesis of PD. Elucidating the role of α-synuclein, and of other PD-associated proteins, in Ca homeostasis could provide new opportunities for developing novel therapeutics to treat synucleinopathies.
Across all kingdoms in the tree of life, calcium (Ca) is an essential element used by cells to respond and adapt to constantly changing environments. In multicellular organisms, it plays fundamental roles during fertilization, development and adulthood. The inability of cells to regulate Ca can lead to pathological conditions that ultimately culminate in cell death. One such pathological condition is manifested Parkinson&aposs disease, the second most common neurological disorder in humans, which is characteriz
A role model is as opposed to . Role models are active in their communities, freely giving of their time and talents to benefit people. Students admired people who served on local boards, reached out to neighbors in need, voted, and were active members of community organizations.Ability to act in ways consistent with the values, beliefs, and moral principles we claim to hold.