Clinical assessments were carried out at baseline and on fortnightly intervals for the first month, then on a monthly basis for the following two months and then at three monthly intervals thereafter concluding at the 12-month time point. The clinical assessment included observer-based ratings using the YMRS for manic symptoms, the Montgomery-Åsberg Depression Rating Scale for depressive symptoms the Brief Psychiatric Rating Scale for overall psychopathology and severity of psychotic symptoms and the Cli
/ Kauer-Sant&aposAnna, Marcia Lam, W. Yatham, Lakshmi N.
Manic and depressive episodes tend to be characterized by ventral versus dorsal dysfunction in the ventral prefrontal cortex. During attentional tasks and resting, mania is associated with decreased activity, while depression is associated with increased resting metabolism. Consistent with affective disorders due to lesions, mania and depression are lateralized in ventral prefrontal cortex (vPFC) dysfunction, with depression primarily being associated with the left vPFC, and mania the right vPFC. Abnormal
White matter neuroimaging metrics that reflect axonal structure, such as fractional anisotropy, and the mean and radial diffusivity are altered in people with BD compared with controls. Alterations in white matter microarchitecture have also been shown to be associated with poorer treatment response. This suggests that there is a process of disturbed myelination in disorder that is seemingly not associated with axonal loss. Such changes can only be assessed with diffusion imaging that may prove more sensiti
, Marcia Kauer-Sant&aposAnna, Raymond W. Lam, Lakshmi N. YathamT1 - Weight gain, obesity, and indices following a first manic episode